Clinical Application of Auricularia Auricular polysaccharide

       Numerous animal studies of Auricularia auricula polysaccharide (AAP) by many scientists in research institutions in China and abroad have proved that AAP has many other beneficial effects:

Increase the level of good cholesterol (HDL)   ·Lower blood sugar levels.   ·Reduce platelet aggregation, hence can prevent stroke.
Enhance blood circulation and reduce blood concentration.
Anti-free radical function which can have anti-cancer effect.
Contains an abundant amount of calcium, magnesium, zinc, vitamin K, vitamin E and other elements, which can strengthen the immune system.
Has very high fiber content, which can help the digestive system and speed up the recovery of the stomach.

AN EAST MEDICINE LTD COMMISSIONED PHASE 2 CLINICAL TRIAL
       A pivotal Phase 2 clinical trial was conducted by the renowned Optum company based in United States of America.

       Optum (www.optum.com) is an independent clinical research company (CRO) in the United States. It is a subsidiary of the world’s second largest health insurance United Health Group, a Fortune 500 company. 

       Based on the U.S. FDA standard, a Phase 2 clinical trial was conducted. It was a 162 subjects, 12 weeks, clinical, multi-centers, randomized, double-blind, placebo control, parallel group study. This clinical trial confirmed that Black Muer can lower total cholesterol (TC), reduce low-density cholesterol (LDL) and improve high-density cholesterol (HDL), without any adverse reactions.


At great cost, East Medicine Ltd has successfully completed this pivotal phase 2 clinical trial to prove beyond doubt that

Black Muer can  · Lower Total and LDL Cholesterol  ·Enhance HDL Cholesterol  ·Without any Adverse Side Effect
Time period Phase one and two usually takes about 5 years
Average Cost Phase one. US$ 4 million  Phase two. US$ 14 million
Phase One and Two  Total US$ 17 million	Source: https://aspe.hhs.gov/report/examination-clinical-trial-costs-and-barriers-drug-development

Health Canada Approval

This pivotal phase 2 clinical trail proved Black Muer is effective in raising HDL, lowering LDL and total cholesterol, without side effect.        The Trial results were reviewed by Health Canada. With that, Black Muer was approval as a Natural Health Product - equivalent to a herbal drug.        Canada is one of the countries in the world with the most stringent regulations of nutrition and health food.        NPN (Natural Product Number) is an official, verified, certificated number in Canada for an all-natural nutritional and health care product. The United States does not have a similar health care product certification system, so such products do not need to be reviewed and approved by the FDA.        With the results of this pivotal study, Health Canada granted Black Muer NPN status (NPN 80000520).

 China Invention Patent

Patent No: ZL202211060080.0         Patent valid for 20 years, until 2042         The preparation method of Auricularia auricula polysaccharide produced by this present invention is simple. The extraction efficiency is high. The quality of Auricularia auricula polysaccharide is of high purity, good solubility, easy to absorb, and with multiple beneficial biological activities.         These benefits include regulate blood lipids by lowering total cholesterol and LDL, and enhancing HDL cholesterol anti-inflamma-tory, anti-aging by reducing free radicals hypoglycemic improve immunity, promote mental alertness.         Utility Patent Pending in USA.